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Therapeutic implications of circadian clocks in neurodegenerative diseases
How body clocks may affect treatment of brain diseases that worsen over time
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Abstract
Circadian abnormalities may influence the progression of neurodegenerative diseases like Alzheimer's and Parkinson's.
- Circadian clocks are involved in controlling various biological processes beyond the master clocks in the suprachiasmatic nucleus.
- Evidence suggests that disruptions in circadian rhythms are linked to sleep disturbances and abnormal rest-activity patterns.
- Altered circadian clocks could act as risk factors for developing neurodegenerative diseases by affecting the production or clearance of toxic metabolites such as amyloid β.
- Current clinical trials are exploring ways to address circadian abnormalities in patients with Alzheimer's and Parkinson's diseases.
- Targeting circadian clocks may enhance treatment efficacy and specificity for neurodegenerative diseases.
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