Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease

Apr 19, 2021Neurochemical research

Understanding How Disrupted Body Clocks and Alzheimer's Disease Affect Each Other

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Alzheimer's disease (AD) is characterized by the accumulation of amyloid beta plaques and neurofibrillary tangles in the brain.

The circadian system is affected in Alzheimer's disease, potentially impacting the sleep/wake cycle.
There is a bidirectional relationship between circadian disruptions and the progression of Alzheimer's disease.
Pathological changes related to sleep disturbances are often observed in individuals with Alzheimer's disease.
Studying the connections between circadian disruption and Alzheimer's may help in identifying the disease earlier.
Insights into circadian mechanisms could lead to improved approaches and potential therapies for dementia.

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Alzheimer's disease (AD) is one of the crucial causative factors for progressive dementia. Neuropathologically, AD is characterized by the extracellular accumulation of amyloid beta plaques and intracellular neurofibrillary tangles in cortical and limbic regions of the human brain. The circadian system is one of the many affected physiological processes in AD, the dysfunction of which may reflect in the irregularity of the sleep/wake cycle. The interplay of circadian and sleep disturbances inducing AD progression is bidirectional. Sleep-associated pathological alterations are frequently evident in AD. Understanding the interrelation between circadian disruption and AD may allow for earlier identification of AD pathogenesis as well as better suited approaches and potential therapies to combat dementia. In this article, we examine the existing literature related to the molecular mechanisms of the circadian clock and interacting mechanisms of circadian disruption and AD pathogenesis.

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Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer’s Disease

Abstract

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