Decoding the Inter-Relationship between Sleep Disorders and Alzheimer’s Disease Pathogenesis

Alzheimer's Disease (AD) is associated with sleep disturbances that may contribute to its pathology.

• Abnormal tau phosphorylation and amyloid deposits are linked to both sleep disorders and Alzheimer's Disease.
• Sleep disturbances may create a positive feedback loop exacerbating AD pathology.
• Melatonin may inhibit tau hyperphosphorylation and amyloid deposition, potentially aiding sleep regulation in AD.
• Astrocytes have a role in worsening Alzheimer's Disease, highlighting their importance in the pathology.
• Various therapeutic approaches, including melatonin supplementation and light therapy, are discussed for addressing both sleep disorders and AD.
• The exact relationship between sleep disorders and Alzheimer's Disease remains unclear, indicating a need for further research.

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