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Abstract
Alzheimer's Disease (AD) is associated with sleep disturbances that may contribute to its pathology.
- Abnormal tau phosphorylation and amyloid deposits are linked to both sleep disorders and Alzheimer's Disease.
- Sleep disturbances may create a positive feedback loop exacerbating AD pathology.
- Melatonin may inhibit tau hyperphosphorylation and amyloid deposition, potentially aiding sleep regulation in AD.
- Astrocytes have a role in worsening Alzheimer's Disease, highlighting their importance in the pathology.
- Various therapeutic approaches, including melatonin supplementation and light therapy, are discussed for addressing both sleep disorders and AD.
- The exact relationship between sleep disorders and Alzheimer's Disease remains unclear, indicating a need for further research.
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