Alzheimer’s disease and sleep disorders: A bidirectional relationship

Aug 13, 2024Neuroscience

How Alzheimer's disease and sleep problems affect each other

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Alzheimer's disease (AD) features abnormal accumulation of amyloid-β (Aβ) and hyperphosphorylated tau.

Sleep disorders could be both risks for and consequences of AD.
There may be a bidirectional relationship between sleep and AD.
Alterations in sleep structure are associated with the progression of AD.
The interaction between Aβ accumulation, hyperphosphorylated tau, and neuroinflammation is significant in AD pathology.
Methods to enhance sleep may help reduce AD-associated neuropathology.

AI simplified

Alzheimer's disease (AD) is the most prevalent dementia, pathologically featuring abnormal accumulation of amyloid-β (Aβ) and hyperphosphorylated tau, while sleep, divided into rapid eye movement sleep (REM) and nonrapid eye movement sleep (NREM), plays a key role in consolidating social and spatial memory. Emerging evidence has revealed that sleep disorders such as circadian disturbances and disruption of neuronal rhythm activity are considered as both candidate risks and consequence of AD, suggesting a bidirectional relationship between sleep and AD. This review will firstly grasp basic knowledge of AD pathogenesis, then highlight macrostructural and microstructural alteration of sleep along with AD progression, explain the interaction between accumulation of Aβ and hyperphosphorylated tau, which are two critical neuropathological processes of AD, as well as neuroinflammation and sleep, and finally introduce several methods of sleep enhancement as strategies to reduce AD-associated neuropathology. Although theories about the bidirectional relationship and relevant therapeutic methods in mice have been well developed in recent years, the knowledge in human is still limited. More studies on how to effectively ameliorate AD pathology in patients by sleep enhancement and what specific roles of sleep play in AD are needed.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Alzheimer’s disease and sleep disorders: A bidirectional relationship

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief