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Sleep and amyloid protein interactions in Alzheimer's disease development
Updated
Abstract
Cognitive impairment in older adults is associated with sleep and circadian rhythm disturbances.
- Disrupted sleep and circadian rhythms are linked to amyloid-β (Aβ), a key factor in Alzheimer's disease (AD).
- Aβ may initiate the pathogenesis of AD, while tau appears to drive neurodegeneration.
- Recent studies suggest that sleep-wake cycles may have a greater impact on brain tau levels than on Aβ levels.
- Alterations in sleep patterns could accelerate AD progression and cognitive decline.
- Understanding sleep disturbances may clarify mechanisms underlying AD and dementia.
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