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Abstract
The worldwide prevalence of Alzheimer's disease is expected to rise from 46.8 million individuals in 2015 to 131.5 million by 2050.
- Alzheimer's disease is characterized by amyloid-β deposition, tau aggregation, neuronal loss, and cognitive decline.
- Sleep disturbances may be linked to an increased risk of developing Alzheimer's disease.
- There is a hypothesized bi-directional relationship between sleep and Alzheimer's disease, where sleep issues could indicate AD pathology or contribute to its progression.
- The review discusses evidence in humans regarding the relationship between sleep and Alzheimer's disease.
- Therapeutic approaches to address sleep disturbances are explored for their potential to prevent or delay Alzheimer's disease onset.
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