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Abstract
Alzheimer's disease is projected to more than double in prevalence over the next 20 years.
- Sleep disturbances are commonly observed in individuals with Alzheimer's disease.
- Age-related sleep issues, such as poor sleep efficiency and sleep apnea, may be linked to future cognitive impairment.
- Amyloid-β aggregation into plaques in the brain is a significant factor in the development of Alzheimer's disease and may start 20 years before dementia symptoms appear.
- Research indicates that amyloid-β levels increase during wakefulness and decrease during sleep, demonstrating a diurnal pattern.
- Animal studies suggest that modifications in sleep duration could influence amyloid-β deposition, indicating a potential connection between sleep and Alzheimer's disease progression.
- A hypothetical model is proposed to explore the relationship between sleep patterns and amyloid-β dynamics in the context of Alzheimer's disease.
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