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Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease
Possible role of orexin and sleep changes in the development of Alzheimer's disease
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Abstract
Knockout of the orexin gene in APP/PS1 transgenic mice led to a marked decrease in Aβ pathology and an increase in sleep time.
- Age-related aggregation of amyloid-β is associated with disrupted sleep-wake cycles.
- In humans with preclinical Alzheimer's disease, poor sleep quality and reduced sleep duration have been noted.
- Loss of orexin-producing neurons is linked to narcolepsy and affects wakefulness.
- Focal overexpression of orexin in the hippocampus did not change total sleep/wakefulness or Aβ pathology.
- Increased wakefulness through orexinergic neuron rescue in orexin-deficient APP/PS1 mice resulted in heightened Aβ pathology.
- Modulation of orexin and its impact on sleep may influence amyloid-β pathology in the brain.
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