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Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Orexin and the sleep-wake cycle influence amyloid-beta levels
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Abstract
The amount of interstitial fluid amyloid-beta (ISF Abeta) in mice is correlated with wakefulness.
- ISF Abeta levels increased significantly during acute sleep deprivation.
- ISF Abeta levels rose with orexin infusion and fell with the use of a dual orexin receptor antagonist.
- Chronic sleep restriction significantly increased Abeta plaque formation in amyloid precursor protein transgenic mice.
- A dual orexin receptor antagonist was associated with a decrease in Abeta plaque formation.
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