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Abstract
Disruption of circadian rhythms and sleep may significantly influence the progression of Alzheimer's disease.
- Alzheimer's disease is associated with cognitive impairment and dysfunction of circadian rhythms.
- There is a mutual relationship among circadian rhythms, sleep, and the progression of Alzheimer's disease.
- Factors such as amyloid β, neurofibrillary tangles, neuroinflammation, and oxidative stress may contribute to Alzheimer's disease through their impact on circadian rhythms.
- Aging can disrupt both sleep quality and timing, which are notably affected in Alzheimer's disease.
- Increased amyloid β production and decreased clearance are linked to sleep disturbances and heightened wakefulness.
- Tau pathology may also play a significant role in sleep deprivation observed in Alzheimer's disease.
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