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Abstract
Disrupted sleep-wake cycles may accelerate the development and progression of Alzheimer's disease.
- Extracellular levels of metabolites, including amyloid beta, increase during wakefulness.
- Sleep aids in the clearance of these metabolites from the brain through fluid flow.
- Disruption of the sleep-wake cycle is associated with reduced clearance of extracellular metabolites.
- Increased levels of the wake-promoting neuropeptide orexin correlate with disrupted sleep patterns.
- Disrupted sleep is linked to heightened neuronal oxidative stress and impaired blood-brain barrier function.
- Alzheimer's disease-related changes can disrupt sleep and circadian rhythms even before clinical symptoms appear.
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