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The sleep–wake Cycle and Alzheimer’s Disease: What do We know?
What We Know About the Sleep-Wake Cycle and Alzheimer's Disease
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Abstract
Sleep-wake disturbances are highly prevalent in Alzheimer's disease (AD) and may disrupt normal sleep patterns due to the accumulation of amyloid-β (Aβ) peptide.
- Amyloid plaques are a key feature of Alzheimer's disease, associated with the buildup of the amyloid-β peptide.
- Accumulation of amyloid-β may lead to increased sleep-wake fragmentation.
- Chronic sleep deprivation is linked to an increase in amyloid plaque deposition.
- Extending sleep may result in a reduction of amyloid plaques in experimental models.
- The sleep-wake cycle may influence the onset and progression of Alzheimer's disease.
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