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Circadian and sleep phenotypes in a mouse model of Alzheimer’s disease characterized by intracellular accumulation of amyloid β oligomers
Daily rhythm and sleep patterns in mice with Alzheimer’s-related buildup of harmful protein clusters
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Abstract
Aβ-GFP transgenic mice showed elongated rapid eye movement (REM) sleep durations compared to wild-type mice.
- Circadian rhythm and free-running activity were similar in Aβ-GFP transgenic and wild-type mice.
- Non-REM sleep and wakefulness durations were not affected in Aβ-GFP transgenic mice.
- Aβ-GFP transgenic mice demonstrated shifts in EEG power spectra towards higher frequencies during the inactive light phase.
- The intracellular accumulation of amyloid beta oligomers may be linked to changes in sleep quality.
- The impact of Aβ oligomers on circadian systems appears to be limited.
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