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Abstract
Disrupted sleep and abnormal circadian rhythms may accelerate Alzheimer's disease (AD) through various biological mechanisms.
- Evidence suggests that sleep deprivation worsens the accumulation of amyloid-beta, a key feature of AD.
- Glymphatic withdrawal, necessary for clearing toxic proteins from the brain, is impaired during sleep deprivation.
- Disturbances in circadian rhythms may induce neuroinflammation and oxidative stress, potentially accelerating neurodegeneration.
- Alzheimer's pathology may further disrupt sleep and circadian function, creating a vicious cycle that exacerbates cognitive decline.
- Targeting sleep and circadian mechanisms could be a potential therapeutic strategy for Alzheimer's disease.
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