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Circadian rhythm disturbances in Alzheimer’s disease: insights from plaque-free and plaque-burdened stages in APPSWE/PS1dE9 mice
Changes in daily body clock patterns during early and advanced Alzheimer's stages in a mouse model
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Abstract
Two-month-old Alzheimer's disease (AD) mice exhibited altered activity patterns compared to wild-type mice, with increased activity during the light phase and decreased activity during the dark phase.
- Significant changes in activity patterns were observed in both 2-month-old and 10-month-old AD mice.
- EEG analysis indicated increased wakefulness and reduced non-rapid eye movement (NREM) sleep in both age groups of AD mice.
- in the suprachiasmatic nucleus, hippocampus, and cortex showed significant alterations in expression in AD mice.
- disturbances in AD mice were noted prior to the deposition of amyloid-beta (Aβ), suggesting early disruption.
- A close correlation exists between circadian clock gene expression levels and specific sleep-wake parameters, particularly in the SCN and hippocampus.
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Key numbers
2 of 10 months
Increased Activity During Light Phase
AD mice showed increased activity during light phases compared to WT mice.
10 months
Reduced NREM Sleep Duration
Average length of NREM sleep was significantly reduced in AD mice at this age.