Changes in daily body clock patterns during early and advanced Alzheimer's stages in a mouse model

Two-month-old Alzheimer's disease (AD) mice exhibited altered activity patterns compared to wild-type mice, with increased activity during the light phase and decreased activity during the dark phase.

• Significant changes in activity patterns were observed in both 2-month-old and 10-month-old AD mice.
• EEG analysis indicated increased wakefulness and reduced non-rapid eye movement (NREM) sleep in both age groups of AD mice.
• Core clock genes in the suprachiasmatic nucleus, hippocampus, and cortex showed significant alterations in expression in AD mice.
• Circadian rhythm disturbances in AD mice were noted prior to the deposition of amyloid-beta (Aβ), suggesting early disruption.
• A close correlation exists between circadian clock gene expression levels and specific sleep-wake parameters, particularly in the SCN and hippocampus.

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