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Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer’s Disease
Changes in Daily Rhythm Gene Activity in Brain Areas of a Mouse Model of Alzheimer's Disease
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Abstract
Light exposure significantly altered clock gene expression in the suprachiasmatic nucleus (SCN) of 3×Tg-AD mice compared to their wild type littermates.
- Circadian disruption is a major feature of Alzheimer's disease, affecting the sleep/wake cycle.
- In 3×Tg-AD mice, light exposure resulted in disrupted patterns of clock gene expression in the SCN, a key area for circadian regulation.
- Gene expression changes were observed in the SCN of both 6- and 18-month-old Non-Tg mice, indicating age-related effects.
- Genotype influenced hippocampal Sirt1 expression and the expression of genes in the brainstem involved in circadian regulation.
- The findings suggest significant impairment in the clock gene pathway during early Alzheimer's development, warranting further investigation.
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Key numbers
+86%
Increase in Bmal1 expression
Bmal1 expression after 12 h exposure to light in Non-Tg mice
–61%
Decrease in Per1 expression
Per1 expression after 12 h exposure to light in Non-Tg mice
+471%
Increase in Cry2 expression
Cry2 expression after 12 h exposure to light in Non-Tg mice