Full text is available at the source.
Abstract
Sleep deprivation and circadian rhythm disruption may increase the risk of developing Alzheimer's disease.
- Sleep deprivation and circadian rhythm disruption may interact to impair the brain's ability to clear harmful substances.
- This impairment could affect the clearance of critical brain proteins like β-amyloid and tau.
- Both conditions may lead to increased oxidative stress in the brain.
- Decreased levels of melatonin in the bloodstream may occur due to sleep deprivation and circadian rhythm disruption.
- There may be a potential link between sleep, circadian rhythm, and the formation of stress granules, suggesting a new pathway in Alzheimer's disease development.
Simplified