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Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: Focus on the role of hypocretin and melatonin
Two-Way Links Between Sleep, Body Clock, and Alzheimer's Disease: The Roles of Wakefulness and Sleep Hormones
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Abstract
Alzheimer's disease (AD) is associated with sleep and circadian disturbances that negatively impact quality of life.
- AD pathology disrupts sleep and circadian rhythms.
- Impairments in sleep regulating systems may link to clinical symptoms in AD.
- Neurotransmitters like melatonin and hypocretin could influence AD pathophysiology.
- Lack of sleep and circadian rhythm deterioration may play a role in the onset of AD.
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