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Abstract
Alterations in circadian rhythms are among the most common and debilitating symptoms in patients with neurodegenerative diseases.
- Disruptions in circadian organization can lead to various health issues.
- The underlying neural circuitry responsible for circadian rhythm generation in neurodegenerative diseases is not well understood.
- Recent studies have focused on the neuropathological status of components within this circuitry.
- Dysfunctions in different nodes of the circadian circuitry may contribute to rhythm alterations in affected patients.
- A better understanding of these mechanisms could aid in the development of targeted therapies.
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