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Circadian rhythm perturbation causes IBS-like characteristics and altered fecal metabolome in mice
Disrupted body clock causes IBS-like symptoms and changes in gut chemicals in mice
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Abstract
Circadian rhythm disturbance led to IBS-like characteristics in mice, including visceral hypersensitivity and colonic hyperpermeability.
- Visceral sensitivity was increased, as measured by the abdominal withdrawal reflex score during colorectal distention.
- Colonic permeability was elevated, indicated by reduced transepithelial resistance and increased permeability to fluorescent dextran.
- Gut microbial diversity decreased, and the structure of gut microbiota was significantly altered.
- Specific microbial genera, such as Bacteroides and Bifidobacterium, were influenced by circadian rhythm disturbance.
- Metabolic profiles of gut microbiota were changed, affecting various metabolites like 1-methylhistamine and nitrosylhaem.
- The relationship between microbial genera and metabolites was altered due to circadian rhythm disturbance.
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Key numbers
40
Increase in Visceral Sensitivity
AWR scores at specific pressures for PN vs. NN groups
0.032
Decrease in Microbial Diversity
Simpson index comparison between NN and PN groups
74
Metabolite Changes
Increased metabolites identified in PN group vs. NN group