Disrupted body clock causes IBS-like symptoms and changes in gut chemicals in mice

Circadian rhythm disturbance led to IBS-like characteristics in mice, including visceral hypersensitivity and colonic hyperpermeability.

• Visceral sensitivity was increased, as measured by the abdominal withdrawal reflex score during colorectal distention.
• Colonic permeability was elevated, indicated by reduced transepithelial resistance and increased permeability to fluorescent dextran.
• Gut microbial diversity decreased, and the structure of gut microbiota was significantly altered.
• Specific microbial genera, such as Bacteroides and Bifidobacterium, were influenced by circadian rhythm disturbance.
• Metabolic profiles of gut microbiota were changed, affecting various metabolites like 1-methylhistamine and nitrosylhaem.
• The relationship between microbial genera and metabolites was altered due to circadian rhythm disturbance.

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