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Chronic restraint stress affects the diurnal rhythms of gut microbial composition and metabolism in a mouse model of depression
Long-term stress changes daily patterns of gut bacteria and metabolism in a mouse model of depression
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Abstract
in mice led to observable depressive-like behaviors after 4 weeks.
- Microbial diversity in both control and stressed mice varied throughout the day.
- Specific bacterial groups, including Bacteroidota and Firmicutes, displayed circadian rhythmicity in stressed mice.
- In control mice, the genus Dubosiella showed rhythmicity and was linked to tryptophan and galactose metabolism.
- In stressed mice, genera such as Bacteroides and Parabacteroides exhibited rhythmicity, with Parabacteroides associated with tryptophan and phenylalanine metabolism.
- Observing the daily oscillation of gut microbiota may provide insights into their role in depressive-like states.
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Key numbers
0.0009
Increase in immobility
Statistical significance in forced swimming test results.
357
357 altered metabolites during light phase
Total number of faecal metabolites changed in group during light hours.
197
197 altered metabolites during dark phase
Total number of faecal metabolites changed in group during dark hours.