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The role of gut microbiota in chronic restraint stress-induced cognitive deficits in mice
How gut bacteria relate to thinking problems caused by long-term stress in mice
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Abstract
Mice with chronic stress and cognitive deficits showed a significant correlation between the gut bacterium Muricomes and cognitive impairment, with a predictive accuracy of 0.96.
- led to reduced movement distances and recognition indices in mice with cognitive deficits compared to those without.
- Five gut bacteria genera were found to be significantly different across control, CRS-NCD, and CRS-CD groups.
- Muricomes were enriched in mice exhibiting cognitive deficits and were associated with lower cognitive performance.
- The gut microbiota composition may play a role in the cognitive deficits observed following chronic stress.
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Key numbers
577.9 cm
Decrease in Movement Distance
Movement distance of -CD mice vs. -NCD group
0.25
Lower Recognition Index
Recognition index of -CD mice vs. -NCD group
0.96
AUC for Muricomes
Area under the ROC curve for Muricomes in predicting -induced cognitive deficits