Preserved circadian rhythms reflected by dim light melatonin onset in patients with KLS

Circadian melatonin profiles remain comparable in Kleine-Levin Syndrome patients during both remission and relapse phases.

• No significant differences were observed in sleep onset and offset times between KLS patients in remission and healthy controls.
• Rest-activity rhythms in KLS patients during remission were similar to those of healthy controls.
• Key circadian melatonin parameters, including dim light melatonin onset, acrophase, amplitude, and midline-estimating statistic of rhythm, showed no significant differences between groups.
• Melatonin timing and amplitude were comparable among KLS patients during remission and relapse phases.

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