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Circadian rhythms as a modulator of gut microbiota-tumor microenvironment crosstalk
Circadian rhythms may influence the interaction between gut bacteria and the tumor environment.
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Abstract
Circadian rhythms may significantly influence gut microbiota and cancer progression.
- disruptions can lead to imbalances in gut microbiota, known as .
- Changes in gut microbiota may alter the (TME) and promote cancer growth.
- Disrupted circadian rhythms could modify the diversity and functions of gut microbiota, affecting metabolites like short-chain fatty acids.
- These metabolic changes may influence immune cell behavior and tumor cell metabolism in the TME.
- Therapeutic strategies targeting the circadian-microbiome connection include chronotherapy and probiotic use.
- More research is needed to clarify how circadian rhythms and gut microbiota interact, and to create personalized treatments for cancer.
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Key numbers
N/A
Decrease in beneficial bacteria
Circadian disruption alters gut microbiota composition.
N/A
Increase in pathogenic bacteria
is linked to cancer risk.
N/A
Potential therapeutic strategies
Therapies include probiotics and fecal microbiota transplantation.