Circadian rhythms as a modulator of gut microbiota-tumor microenvironment crosstalk

🥉 Top 5% JournalNov 19, 2025Cellular and molecular life sciences : CMLS

Circadian rhythms may influence the interaction between gut bacteria and the tumor environment.

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Abstract

Circadian rhythms may significantly influence gut microbiota and cancer progression.

Circadian rhythm disruptions can lead to imbalances in gut microbiota, known as dysbiosis.
Changes in gut microbiota may alter the tumor microenvironment (TME) and promote cancer growth.
Disrupted circadian rhythms could modify the diversity and functions of gut microbiota, affecting metabolites like short-chain fatty acids.
These metabolic changes may influence immune cell behavior and tumor cell metabolism in the TME.
Therapeutic strategies targeting the circadian-microbiome connection include chronotherapy and probiotic use.
More research is needed to clarify how circadian rhythms and gut microbiota interact, and to create personalized treatments for cancer.

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Circadian rhythms play a pivotal role in regulating diverse physiological functions, notably the composition and activity of gut microbiota. Accumulating evidence indicates that circadian rhythm disruption can induce dysbiosis of the gut microbiome, which in turn is implicated in influencing the tumor microenvironment (TME) and facilitating cancer progression. This review integrates and analyzes recent advances elucidating the complex interplay where circadian rhythms modulate gut microbiota, and how these circadian-driven microbial changes affect the TME. This review analyzes recent advances in elucidating the complex interplay among circadian rhythms, gut microbiota, and the TME. We examine how circadian disruption modifies the diversity and metabolic functions of gut microbiota, resulting in alterations of microbial metabolites, including but not limited to short-chain fatty acids and secondary bile acids. These metabolic alterations have the potential to modulate immune cell function, vascular remodeling, and tumor cell metabolism within the TME. We investigate the potential mechanisms through which gut microbial dysbiosis induced by circadian misalignment could promote an immunosuppressive TME and accelerate tumor growth. Additionally, we evaluate emerging therapeutic strategies that leverage the circadian-microbiome axis, encompassing chronotherapy, probiotic supplementation, and fecal microbiota transplantation. The integration of circadian biology, microbiology, and cancer immunology presents promising avenues for the development of novel diagnostic and therapeutic approaches. However, significant challenges persist in translating these findings into viable clinical applications. Further research is imperative to elucidate the molecular pathways interconnecting circadian rhythms, gut microbiota, and the TME, and to develop personalized chronobiological interventions for cancer prevention and treatment.

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