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Circadian rhythms, insulin action, and glucose homeostasis
How Body Clocks Affect Insulin Function and Blood Sugar Balance
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Abstract
Circadian misalignment is associated with increased insulin resistance and decreased pancreatic function.
- Murine studies indicate a mechanistic link between the circadian clock and metabolic disease development.
- Clock gene polymorphisms and altered expression due to circadian misalignment may contribute to obesity and diabetes in humans.
- Exposure to light at night is linked to lower nocturnal melatonin levels, which appears to affect glucose metabolism.
- Potential therapies for circadian misalignment include timed light exposure, melatonin, and restricting food intake to daytime hours.
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