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Pregnancy-induced changes in the circadian expression of hepatic clock genes: implications for maternal glucose homeostasis
Pregnancy changes daily liver clock gene patterns linked to mother's blood sugar control
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Abstract
Hepatic clock gene expression in pregnant mice showed a 64% reduction in amplitude by day 18 of pregnancy.
- Changes in the expression of clock genes in the liver were observed throughout pregnancy, particularly in late gestation.
- By day 18 of pregnancy, the circadian rhythmicity of several clock genes was significantly attenuated.
- A decline in the rhythmicity of key glucoregulatory genes was noted, with Pck1 losing its rhythmic expression by day 18.
- These adaptations in liver clock genes may contribute to altered circadian variation in glucose-regulating genes as pregnancy progresses.
- The observed reduction in daily oscillations of glucose metabolism could help maintain glucose supply for fetal growth.
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