A rhythmic placenta? Circadian variation, clock genes and placental function

Circadian clock genes are implicated in placental function and may influence maternal health during pregnancy.

• Physiological rhythms regulated by the circadian clock are found in all organs, including the reproductive system.
• A master clock in the suprachiasmatic nucleus drives peripheral tissue clocks through various signals.
• Clock genes generate oscillations that regulate the expression of downstream genes, affecting bodily functions.
• Disruptions in clock gene expression are associated with conditions like cancer and obesity.
• Evidence suggests that clock genes are expressed in the placenta, linking circadian disruption to placental dysfunction.
• Further research is needed to understand the role of placental clock genes throughout gestation and in different species.

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