Daily Changes in Blood Sugar in Male Mice Linked to the Body Clock in the Liver

Fasting blood glucose (FBG) levels exhibit significant daily rhythms, peaking at the beginning of the dark phase.

• FBG rhythms were observed in both normal and diabetic mice, indicating a potential link to the hepatic clock.
• Light-phase restricted feeding altered the FBG rhythm phase more significantly in diabetic ob/ob mice compared to normal C57BL/6J mice.
• The disruption of the hepatic clock gene Bmal1 resulted in the loss of rhythmicity in FBG and glucose transporter expression.
• Octreotide treatment reduced plasma growth hormone levels but did not influence the expression of clock genes or the FBG rise in C57BL/6J mice.

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