Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney

Key circadian clock genes show disrupted expression patterns in liver metastases, with 24-hour oscillations absent except for one gene.

• Healthy control mice exhibit normal 24-hour rhythmic expression of circadian clock genes and clock-controlled genes in liver and kidney tissues.
• In liver metastases from C26 colorectal carcinoma, expression of most clock genes and clock-controlled genes is disrupted, with only Cry1 maintaining oscillation.
• A phase advance is observed in the circadian rhythm of liver tissue from tumor-bearing mice, while kidney tissue shows a phase delay.
• These findings suggest that liver metastases may alter the circadian rhythms of surrounding healthy tissues, affecting their clock systems.

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