Peripheral circadian clocks are diversely affected by adrenalectomy

Adrenalectomy significantly inhibited the mRNA levels of core clock genes in peripheral tissues such as visceral adipose tissue, liver, and jejunum.

• The phase of clock gene rhythms remained unchanged following adrenalectomy.
• Clock gene mRNA levels were modulated in a tissue-specific manner, demonstrating distinct responses across different organs.
• Per1 mRNA levels were notably decreased in visceral adipose tissue, liver, and jejunum post-adrenalectomy.
• Other clock genes, including Per2 and Per3, also showed varying levels of down-regulation or up-regulation in specific tissues.
• Adrenalectomy resulted in lower Gilz mRNA levels without affecting the phase of its diurnal rhythm.
• Circulating corticosteroids are necessary for maintaining high-amplitude rhythmicity of peripheral clocks.

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