Biochemical and biophysical research communications

Daily rhythms of body clock genes in blood cells and beard hair cells

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Abstract

All 13 subjects exhibited prominent daily rhythms in melatonin and cortisol secretion.

  • Significant circadian rhythmicity was observed for the clock gene PER3 in all 13 subjects' leukocytes.
  • PER1 showed significant rhythmicity in leukocytes for 9 subjects, while PER2 was rhythmic in 3 subjects.
  • In beard hair follicle cells, PER3 demonstrated significant rhythmicity in 6 of 8 subjects tested.
  • The phase of PER1 and PER3 rhythms in leukocytes significantly correlated with physiological rhythms.
  • Leukocytes and beard hair follicle cells may serve as effective sources for evaluating biological clock traits.

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