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The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise
How Body Clocks Affect Muscle and Bone Health and Their Control by Diet and Exercise
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Abstract
The mammalian circadian clock influences the rhythmic expression of genes in a tissue-specific manner.
- The circadian clock consists of a central clock in the suprachiasmatic nucleus and peripheral clocks in various tissues.
- Musculoskeletal functions exhibit diurnal variations that are regulated by the circadian clock.
- Tissue-specific circadian rhythms impact the expression of rhythmic genes in skeletal muscle and bone.
- Peripheral clocks respond not only to light signals from the SCN but also to external factors like feeding and exercise.
- Chrono-nutrition and chrono-exercise may have therapeutic potential for addressing circadian disturbances and maintaining homeostasis in skeletal muscle and bone.
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