Circadian Rhythms in Neurospora crassa: Clock Mutant Effects in the Absence of a frq-Based Oscillator

Strains lacking a functional FWC oscillator exhibited rhythmic conidiation when geraniol or farnesol was added to the media.

• Clock mutations in Neurospora can be categorized into three classes based on their effects in a frq(10) or wc-2Delta-null background.
• Some mutations, like prd-3, prd-4, and frq(1), showed no effect in a clock null background.
• Other mutations, including prd-1, prd-2, and prd-6, demonstrated measurable effects in the frq(10) background.
• A new mutation, ult, was identified that negated the need for geraniol or farnesol for a visible rhythm.
• This classification indicates that certain clock mutations may be components of a larger multioscillator system.

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