Two Circadian Timing Circuits in Neurospora crassa Cells Share Components and Regulate Distinct Rhythmic Processes

The study provides evidence that a temperature-responsive, temperature-compensated circadian oscillator drives rhythmic expression of the ccg-16 gene in Neurospora crassa cells lacking FRQ.

• ccg-16 exhibits a robust daily rhythm even in the absence of the FRQ protein.
• The identified FLO is associated with circadian rhythmicity and requires functional WC-1 and WC-2 proteins.
• FRQ is not necessary for maintaining rhythmic levels of WC-1 protein.
• The findings suggest the presence of two circadian oscillators that may interact via shared WC proteins.

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