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Circadian rhythms in the release of vasoactive intestinal polypeptide and arginine-vasopressin in organotypic slice culture of rat suprachiasmatic nucleus
Daily rhythms of two key signaling molecules in rat brain’s internal clock tissue
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Abstract
The total vasoactive intestinal polypeptide (VIP) amount in the medium over 24 hours was six times larger than that of arginine-vasopressin (AVP).
- VIP levels in the medium of organotypic suprachiasmatic nucleus (SCN) cultures exhibited a circadian rhythm with an approximate 22-hour period.
- AVP levels also displayed similar circadian rhythms with the same period in the SCN culture.
- The peak time of the VIP rhythm occurred slightly earlier than that of the AVP rhythm.
- These findings indicate that VIP is released in a rhythmic pattern from the ventrolateral SCN.
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