Journal of translational medicineJul 31, 2026

Blood particles carrying microRNAs as possible markers to identify ME/CFS and distinguish it from other fatigue conditions

Long Covid Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Aug 3, 2026

Abstract

Circulating extracellular vesicles (EVs) may be associated with diagnostic signatures in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Definitive diagnostic molecular markers for ME/CFS are currently lacking.
Identifying microRNAs associated with EVs could help differentiate ME/CFS from idiopathic chronic fatigue and depression.
The study looks to uncover insights into the underlying pathophysiology of ME/CFS through these microRNAs.
ME/CFS shares clinical features with long COVID, highlighting the need for effective diagnostic tools.

Simplified

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating, multi-systemic condition that has gained renewed global attention due to its clinical overlap with the growing population of long COVID patients. Despite ongoing efforts to characterize the disease, definitive diagnostic molecular markers are yet to be fully established, posing challenges in clinically differentiating from idiopathic chronic fatigue (ICF) and depression (Dep). This study aimed to identify circulating extracellular vesicles (EVs)-associated microRNAs (miRNAs) that serve as both diagnostic signatures and windows into the disease's underlying pathophysiology.

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PubMed

Blood particles carrying microRNAs as possible markers to identify ME/CFS and distinguish it from other fatigue conditions

Abstract

Full Text

Funding

Competing interests

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