Clinical and metabolic phenotyping of continuous versus intermittent ENteral NUTrition in ventilated adults with shock: ENNUT trial protocol

Aug 1, 2025BMJ open

Clinical and metabolic differences between continuous and intermittent tube feeding in ventilated adults with shock

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Abstract

A total of 174 critically ill patients will be enrolled to evaluate the effects of intermittent versus continuous enteral nutrition.

Intermittent enteral nutrition may activate protective metabolic pathways by mimicking fasting.
Continuous enteral nutrition could inhibit processes such as autophagy and ketogenesis.
The primary outcome measures changes in the Sequential Organ Failure Assessment (SOFA) score over 7 days.
Secondary outcomes include nutritional intake, metabolic markers, gastrointestinal tolerance, and infection rates.
Quality of life will be assessed at the time of discharge.

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INTRODUCTION: Critically ill patients often require enteral nutrition, but the optimal feeding strategy-continuous or intermittent-remains uncertain. While continuous enteral nutrition ensures steady nutrient delivery, it may inhibit key metabolic and cellular processes such as autophagy and ketogenesis. Intermittent enteral nutrition, by mimicking fasting periods, could activate protective pathways, potentially improving clinical outcomes. However, evidence for its efficacy and safety in intensive care units (ICUs) is limited. This study evaluates the clinical and metabolic impacts of fasting intervals during intermittent enteral nutrition compared with continuous enteral nutrition in critically ill patients.

METHODS AND ANALYSIS: We designed a multicenter, randomised, open-label trial across nine French ICUs, enrolling adult patients requiring mechanical ventilation and vasopressor support. Participants will receive either intermittent or continuous enteral nutrition for 7 days, with the primary endpoint being the change in the Sequential Organ Failure Assessment (SOFA) score from Day 1 to Day 7 or ICU discharge. Secondary endpoints include nutritional intake, metabolic markers, gastrointestinal tolerance, ICU-acquired infections and mortality rates. Quality of life will be assessed at discharge. A total of 174 patients will be included. Descriptive statistics will summarise group characteristics, with the Student's t-test or the Mann-Whitney U test depending on data distribution for SOFA score change, and regression for confounders. Secondary endpoints will be analysed using regression, χor Fisher's exact test, as appropriate. 2

ETHICS AND DISSEMINATION: The study protocol was approved by a French ethics committee on 24 October 2023 (Comité de Protection des Personnes Ile de France 1, Paris, France, number SI 23.03427.000435). Patients are included after providing informed consent. Results will be submitted for publication in a peer-reviewed journal.

TRIAL REGISTRATION NUMBER: Registered on clinicaltrials.gov on 26 March 2023 (NCT06330610).

Key numbers

174

Total Participants

Total number of patients to be included in the trial.

SOFA Score Change

Expected difference in SOFA score between the two feeding strategies.

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Clinical and metabolic phenotyping of continuous versus intermittent ENteral NUTrition in ventilated adults with shock: ENNUT trial protocol

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