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Impact of daily cyclic enteral nutrition versus standard continuous enteral nutrition in critically ill patients: a study protocol for a randomised controlled trial in three intensive care units in France (DC-SCENIC)
Daily Cyclic Feeding Compared to Continuous Feeding in Critically Ill Patients: Study Plan for a Randomized Trial in French Intensive Care Units
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Abstract
A sample size of 318 patients is expected for the ongoing trial comparing daily cyclic enteral nutrition and standard continuous enteral nutrition in ICU patients.
- The trial aims to evaluate if a fasting-mimicking diet can reduce organ failure in ventilated patients during the acute phase of ICU management.
- Primary endpoint is the change in the score at 7 days from study inclusion.
- Secondary outcomes include daily caloric and protein delivery, digestive and respiratory tolerance, metabolic tolerance, 28-day mortality, duration of mechanical ventilation, and ventilator-free days.
- Patients involved are aged 18 years or older, receiving invasive mechanical ventilation, and require enteral nutrition.
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Key numbers
318
Sample Size
Total number of patients expected to be recruited by February 2026.
4 vs. 6
Primary Endpoint Change in Score
Estimated mean Δ scores for continuous and daily cyclic feeding groups.