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Abstract
Oscillatory promoter-enhancer interactions were discovered along the 24-h cycle in mouse liver and kidney tissues.
- Daily active enhancers may modulate rhythmic gene transcription in mammalian tissues.
- Rhythms in chromatin interactions were abolished in arrhythmic knockout mice.
- Deleting a specific intronic enhancer element compromised rhythmic chromatin contacts in tissues.
- The deletion also reduced the daily dynamics of transcriptional burst frequency.
- Remarkably, it shortened the circadian period of locomotor activity rhythms.
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