The gene Per1 may control daily rhythms in memory storage in the hippocampus

Mice exhibit better long-term memory performance during the day compared to night, with improved memory consolidation identified as the key factor.

• Memory performance is influenced by the time of day, showing a significant difference between day and night.
• The enhanced memory during the day is specifically linked to memory consolidation, not acquisition or retrieval.
• The circadian clock gene Period1 (Per1) is identified as a critical mechanism supporting this diurnal variation in memory consolidation.
• Learning-induced oscillations of Per1 correlate with changes in memory performance within the hippocampus.
• Local reduction of Per1 levels in the dorsal hippocampus impairs spatial memory without disrupting circadian rhythms or sleep.

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