We can’t show the full text here under this license. Use the link below to read it at the source.
Clockwork conditioning: Aligning the skeletal muscle clock with time-of-day exercise for cardiometabolic health
Matching the muscle’s internal clock with exercise timing to improve heart and metabolism health
AI simplified
Abstract
Circadian disruption is associated with the onset and progression of cardiometabolic disorders.
- Circadian rhythms synchronize gene expression and physiological processes with environmental time-of-day changes.
- Every mammalian cell contains a core clock mechanism that regulates rhythmic gene expression through a feedback loop.
- The central clock in the hypothalamus is particularly sensitive to light, while peripheral clocks respond to factors like feeding and activity.
- Skeletal muscle circadian clocks show sensitivity to exercise timing, which may influence cardiometabolic health.
- Exercise at different times of day can shift the skeletal muscle clock, suggesting potential therapeutic applications for cardiometabolic diseases.
AI simplified