Metabolism and exercise: the skeletal muscle clock takes centre stage

The skeletal muscle clock plays a crucial role in metabolic health by regulating muscle physiology.

• Circadian rhythms are important for maintaining homeostasis and overall health in mammals.
• The molecular clock, present in nearly every cell, influences physiological outcomes.
• Core clock factors such as BMAL1 and CLOCK work with MYOD1 to regulate muscle function and metabolism.
• The timing of exercise can affect the phase of the skeletal muscle clock.
• Interactions between exercise and the skeletal muscle clock may enhance metabolic health.
• Exercising at specific times could serve as a potential chronotherapeutic strategy for improving metabolic health.

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