type VII is identified as a significant target protein for mitigating age-related decline.
Collagen was found to be associated with lifespan in long-lived mutants through transcriptomic data analysis.
The study confirmed that collagen peptides have a positive impact on lifespan.
factors and functional assays in skin fibroblasts provided additional evidence for collagen's role in aging.
Collagen type VII may serve as a marker of organismal longevity across various aging pathways.
The findings suggest collagen type VII could be a therapeutic target for promoting healthy aging and skin health.
Simplified
Longevity genes and senescence-related signaling proteins are crucial targets in aging research, which aims to enhance the healthy period and quality of life. Identifying these target proteins remains challenging because of the need for precise categorization and validation methods. Our multifaceted approach combined bioinformatics with transcriptomic data to identify as a key element associated with the lifespan of the model organism,. By analyzing transcriptomic data from long-lived mutants that involved mechanisms such as antioxidation, dietary restriction, and genetic background, we identified collagen as a common longevity-associated gene. We validated these findings by confirming that collagen peptides positively affect lifespan, thereby strengthening the validity of the target. Further verification through factors inand functional assays in skin fibroblasts provided additional evidence of the role of collagen in organismal aging. Specifically, our study revealed that collagen type VII is a significant target protein for mitigating age-related decline. By validating these findings across different aging models and cell-based studies, we present compelling evidence for the anti-aging effects of collagen type VII, highlighting its potential as a target for promoting healthy aging. This study proposes that collagen not only serves as an indicative marker of organismal longevity across various senescence-related signaling pathways, but also offers a mechanistic understanding of skin degeneration. Consequently, collagen is an effective target for interventions aimed at mitigating skin aging. This study underscores the potential of collagen type VII (bonding collagen T7) as a therapeutic target for enhancing skin health and overall longevity. Caenorhabditis elegans C. elegans
Key numbers
1.9–20.9%
Lifespan Increase with COL7A1
Percentage increase in lifespan observed in C. elegans treated with COL7A1.
1.7×
Type I Synthesis Increase
Increase in type I synthesis in human skin fibroblasts with COL7A1 treatment.
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