Colonic Epithelial Surfactant Protein D Expression Correlates with Inflammation in Clinical Colonic Inflammatory Bowel Disease

A strong positive correlation (R2 = 0.78, P < 0.0001) exists between surfactant protein D expression and inflammatory activity in surgical specimens from patients with inflammatory bowel disease.

• Increased expression of surfactant protein D (SP-D) in the intestinal epithelium may be linked to higher inflammatory activity in IBD patients.
• Colonic epithelial SP-D expression was very low in mice, and its deficiency did not affect the severity of DSS-induced colitis.
• DSS treatment did induce mild transcription of SP-D in mouse colonic tissue.
• The findings suggest that while SP-D correlates with inflammation in humans, its role in mouse models remains unclear.
• Further research is needed to clarify the protective potential of increased SP-D expression against intestinal inflammation in humans.

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