Comparison of the associations between life's essential 8 and life's simple 7 with stroke: NHANES 1999–2018

Jan 14, 2025Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Comparing how two heart health scores relate to stroke risk: NHANES 1999-2018

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Moderate cardiovascular health (CVH) associated with Life's Essential 8 (LE8) is linked to a 41% lower risk of stroke compared to low CVH.

High CVH associated with LE8 linked to a 71% lower prevalence of stroke compared to low CVH.
Average CVH associated with Life's Simple 7 (LS7) linked to a 24% lower prevalence of stroke compared to inadequate CVH.
Optimal CVH associated with LS7 linked to a 39% lower prevalence of stroke compared to inadequate CVH.
LE8 demonstrated a stronger ability to predict stroke than LS7, with an area under the curve (AUC) of 0.702 versus 0.677.
Oxidative stress and inflammation may mediate the association between LE8 and stroke.
Neither LE8 nor LS7 were predictive of mortality risk in stroke survivors.

AI simplified

OBJECTIVE: This study aims to explore the association between Life's Essential 8 (LE8) and stroke and all-cause mortality, and compare whether it has an advantage over Life's Simple 7 (LS7).

METHODS: This study investigated data from NHANES spanning from 1999 to 2018. The LE8 was categorized as low, moderate and high cardiovascular health (CVH). LS7 score was categorized as inadequate, average, or optimal. Weighted logistic regression and restricted cubic spline (RCS) were used to examin correlations. Receiver operating characteristic (ROC) curves were employed to detect the accuracy in predicting stroke. The stratified and sensitivity analyses were conducted along with mediation analysis. In addition, a longitudinal cohort was constructed by combining the mortality data, and Cox regression models were utilized to determine the association between CVH and the mortality rate.

RESULTS: For LE8, compared to low CVH, moderate CVH was associated with a 41 % lower risk of stroke, and high CVH was associated with a 71 % lower prevalence of stroke. For LS7, compared to inadequate CVH, average CVH was associated with a 24 % lower prevalence of stroke, and optimal CVH was associated with a 39 % lower prevalence of stroke. RCS showed inverse dose-response relationships of both LE8 and LS7 with stroke. In unweighted ROC, LE8 (AUC = 0.702, 95 % CI: 0.685-0.718, P < 0.001) has a stronger ability to discriminate stroke than LS7 (0.677, 95 % CI: 0.658-0.696, P < 0.001) (P= 0.046). Sensitivity analyses demonstrated robustness of LE8 in predicting stroke. GGT and WBC mediated 4.92 % and 4.58 % of the association, respectively. Cox regression showed neither LE8 nor LS7 were predictive of mortality risk among stroke survivor. DeLong

CONCLUSIONS: LE8 outperformed LS7 in classifying stroke. Oxidative stress and inflammation mediated the association between LE8 and stroke.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Comparison of the associations between life's essential 8 and life's simple 7 with stroke: NHANES 1999–2018

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief