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Abstract
The long-term health effects of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) remain unclear.
- There is controversy regarding the development of GIP agonists versus antagonists.
- The potential effects and side effects of GIP therapies in clinical settings are not well understood.
- Further research is needed to explore the impacts of lowering GIP alone or enhancing GLP-1.
- Tree-structured phenotypic modeling and factorial Mendelian randomization analyses could be useful in investigating these effects.
- Higher circulating GLP-1 levels may only indicate minimal activation achieved with DPP-4 inhibitors, not with GLP-1 receptor agonists.
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