Aesthetic plastic surgery

Computer Study of Preventive Biostimulator Treatments to Reduce Facial Sagging Linked to Weight Loss from GLP-1 Drugs

Updated

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) like semaglutide induce rapid weight loss.

  • Weight loss from GLP-1 RAs may lead to facial fat reduction.
  • Rapid loss of facial fat is associated with sagging skin due to decreased soft-tissue support.
  • Preventive strategies to mitigate sagging are currently unvalidated.
  • Conducting prospective trials to evaluate these strategies is challenging.

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Funding

Competing interests

Declarations. Conflict of interest: Dr Rao worked as a consultant and speaker for Allergan Aesthetics an AbbVie company (Irvine, CA); Dr Michon is a consultant, and speaker for Allergan Aesthetics an AbbVie Company), consultant for Galderma Canada and SkinCeuticals Canada, L’Oréal Paris; Dr Joseph is an investigator and advisory board member for Allergan Aesthetics, an AbbVie company (Irvine, CA); clinical investigator for Galderma (Lausanne, Switzerland), Merz (Raleigh, NC), Evolus (Newport Beach, CA), Revance (Newark, CA), and Croma (Leobendorf, Austria); speaker or consultant for Galderma, Merz, and Evolus; advisor for Revance and Croma; and shareholder for Evolus and Revance. Dr Joseph is the Chief Medical Officer for Amalfi-Bio. Dr Wu is a speaker and consultant for Allergan Aesthetics an AbbVie Company, Merz Pharmaceuticals GmbH; Dr Webb is the founder of AesthetiSIM. Dr Rahman, Dr Saklayen and Dr Ahmed have nothing to declare. Human Rights and Animal Participants: This article does not contain any studies with human participants or animals performed by any of the authors. Informed Consent: For this type of study, informed consent is not required. However, explicit consent was obtained to use photography for publication.
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