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Abstract
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) like semaglutide induce rapid weight loss.
- Weight loss from GLP-1 RAs may lead to facial fat reduction.
- Rapid loss of facial fat is associated with sagging skin due to decreased soft-tissue support.
- Preventive strategies to mitigate sagging are currently unvalidated.
- Conducting prospective trials to evaluate these strategies is challenging.
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