Constant light exposure alters gut microbiota and short‐/medium‐chain fatty acids and aggravates PCOS‐like traits in HFD‐fed rats

Constant light exposure aggravated PCOS-like phenotypes in high-fat diet-fed rats.

• Hyperandrogenism and disrupted estrous cycles were observed in rats exposed to constant light.
• Polycystic ovaries developed in high-fat diet-fed rats under constant light conditions.
• Constant light exposure and a high-fat diet reduced gut microbiota diversity.
• There was a decreased abundance of the Ruminococcus genus and an increased abundance of Firmicutes.
• An increase in propionate acid and a decrease in total medium-chain fatty acids were noted in the colon contents of high-fat diet-fed rats under constant light.

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