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Developing a system that considers surroundings to understand cell aging
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Abstract
Essence
Cellular senescence is better framed as a dynamic, context-dependent spectrum than a universal binary state.
Evidence
This conceptual review synthesizes evidence on unstable growth arrest, senotype diversity, tissue and stressor effects, timing, and disease context.
Caveat
Because it is a framework proposal rather than a primary experiment, it does not validate specific biomarkers, senolytics, or intervention rules.
Simplified
Longevity & Aging