Effects of Continuous Positive Airway Pressure on Quality of Life in Patients With Moderate to Severe Obstructive Sleep Apnea: Data From a Randomized Controlled Trial

Nov 19, 2008Sleep

Continuous positive airway pressure and quality of life in people with moderate to severe obstructive sleep apnea

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Real CPAP was superior to sham CPAP with an effect size of 1.33 for subjective sleepiness.

Real CPAP significantly reduced subjective sleepiness compared to sham CPAP, as measured by the Epworth Sleepiness Scale (ESS).
The patient's component from the Dublin questionnaire showed a notable effect size of 0.98, indicating improved quality of life for patients.
Social interactions, assessed through the Calgary Sleep Apnea Quality of Life Index (SAQLI), also demonstrated a significant effect size of 0.92.
ESS had the highest predictive power for determining real CPAP response, with a P-value less than 0.0001.
Specific items from the Dublin and ESS questionnaires were identified as the best predictors of real CPAP response.

AI simplified

STUDY OBJECTIVES: Previous studies have shown that CPAP has a substantial impact on daytime symptoms and quality of life (QOL). It remains unclear which outcome measures best identify real CPAP effects and carry independent information.

METHODS: One hundred-two men with moderate-severe obstructive sleep apnea were randomized to either "real" or "sham" CPAP for one month. Outcome measures were subjective sleepiness (Epworth Sleepiness Scale [ESS]) and QOL measures includiig SF-36/SF-12 and Calgary Sleep Apnea Quality of Life Index (SAQLI). The bed partner's QOL and rating of patient's response to CPAP were assessed with the Dublin questionnaire. All data were standardized using effect sizes and expressed as real minus sham to remove the nonspecific effects of placebo.

RESULTS: Real CPAP was superior to sham CPAP in almost all outcome measures. ESS, patient's component from Dublin, and social interactions from SAQLI showed the largest differences in effect sizes between real and sham (1.33, 0.98, and 0.92 respectively). ESS carried the highest predictive power of real CPAP response (P < 0.0001, r2 = 0.21). Question number 5 from Dublin (partner assessed patient's sleep quality) and question 6 from ESS (dozing while talking) were the best single item predictors of real CPAP response.

CONCLUSIONS: Real CPAP reduces subjective sleepiness and improves QOL of both patients and bed partners. ESS is the best score; question number 5 from Dublin and question number 6 from ESS are the best single item predictors of real CPAP response. This information should allow the selection of appropriate questions in clinical practice and research protocols.

Full Text

Full text is available at the source.

View full text ↗

Effects of Continuous Positive Airway Pressure on Quality of Life in Patients With Moderate to Severe Obstructive Sleep Apnea: Data From a Randomized Controlled Trial

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief